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PAI3 Pai3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855212, updated on 9-Dec-2024

Summary

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Official Symbol
PAI3
Official Full Name
Pai3p
Primary source
SGD:S000004786
Locus tag
YMR174C
See related
AllianceGenome:SGD:S000004786; FungiDB:YMR174C; VEuPathDB:YMR174C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endopeptidase inhibitor activity. Involved in protein catabolic process in the vacuole. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PAI3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (610159..610365, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Hot1p Neighboring gene DNA damage-responsive protein 48 Neighboring gene uncharacterized protein Neighboring gene Sip18p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification, co-crystallization and preliminary X--ray analysis of the natural aspartic proteinase inhibitor IA3 complexed with saccharopepsin from Saccharomyces cerevisiae. Badasso MO, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jul. PMID 10930843
  2. N-terminal extension of the yeast IA3 aspartic proteinase inhibitor relaxes the strict intrinsic selectivity. Winterburn TJ, et al. FEBS J, 2007 Jul. PMID 17608726
  3. Key features determining the specificity of aspartic proteinase inhibition by the helix-forming IA3 polypeptide. Winterburn TJ, et al. J Biol Chem, 2007 Mar 2. PMID 17145748
  4. Quantitative structure activity relationship of IA3-like peptides as aspartic proteinase inhibitors. Padrón-García JA, et al. Proteins, 2009 Jun. PMID 19003993
  5. Adaptation of the behaviour of an aspartic proteinase inhibitor by relocation of a lysine residue by one helical turn. Winterburn TJ, et al. Biol Chem, 2006 Aug. PMID 16895485

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process in the vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pai3p
NP_013899.1
  • Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    610159..610365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182680.1 → NP_013899.1  TPA: Pai3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013899.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZZ6, P01094
    UniProtKB/TrEMBL
    A6ZMN3, B3LM60, C7GTS7, C8ZF36, G2WKM7, N1P0F8
    Conserved Domains (1) summary
    pfam10466
    Location:1 → 68
    Inhibitor_I34; Saccharopepsin inhibitor I34
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01094.1

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