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MMT1 Mmt1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855215, updated on 9-Dec-2024

Summary

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Official Symbol
MMT1
Official Full Name
Mmt1p
Primary source
SGD:S000004789
Locus tag
YMR177W
See related
AllianceGenome:SGD:S000004789; FungiDB:YMR177W; VEuPathDB:YMR177W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MFT1
Summary
Predicted to enable monoatomic cation transmembrane transporter activity. Involved in intracellular iron ion homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MMT1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (616566..618098)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ecm5p Neighboring gene Fpy1p Neighboring gene Spt21p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of iron transport to the site of heme synthesis inside yeast mitochondria. Lange H, et al. J Biol Chem, 1999 Jul 2. PMID 10383398
  2. Characterization of two homologous yeast genes that encode mitochondrial iron transporters. Li L, et al. J Biol Chem, 1997 Nov 7. PMID 9353309
  3. Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. Ward DM, et al. J Biol Chem, 2018 Jul 6. PMID 29773647, Free PMC Article
  4. Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase. Jensen LT, et al. J Biol Chem, 2004 Jul 16. PMID 15107423
  5. Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export. Li L, et al. J Biol Chem, 2014 Jun 13. PMID 24798331, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
    Title: The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
  2. Overexpression of MMT1 affects cytosolic iron independent of CCC1.
    Title: Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables monoatomic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inorganic ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mmt1p
NP_013902.1
  • Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    616566..618098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182683.1 → NP_013902.1  TPA: Mmt1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W000, Q03218, Q66R35
    UniProtKB/TrEMBL
    B3LM63, B5VPU5, C7GTS4, C8ZF40, G2WKN1, N1NYX1
    Conserved Domains (1) summary
    COG0053
    Location:150 → 488
    FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03218.1

Gene LinkOut

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