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MGL2 putative carboxylic ester hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855250, updated on 9-Dec-2024

Summary

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Official Symbol
MGL2
Official Full Name
putative carboxylic ester hydrolase
Primary source
SGD:S000004823
Locus tag
YMR210W
See related
AllianceGenome:SGD:S000004823; FungiDB:YMR210W; VEuPathDB:YMR210W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables monoacylglycerol lipase activity and triacylglycerol lipase activity. Involved in medium-chain fatty acid biosynthetic process and triglyceride metabolic process. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MGL2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (687516..688865)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mevalonate kinase Neighboring gene uncharacterized protein Neighboring gene Dml1p Neighboring gene Efr3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ymr210wp leads to the accumulation of phospholipids and steryl esters in yeast. Manda NK, et al. Bioinformation, 2017. PMID 29225428, Free PMC Article
  2. MGL2/YMR210w encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. Selvaraju K, et al. FEBS Lett, 2016 Apr. PMID 26991558
  3. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. Saerens SM, et al. J Biol Chem, 2006 Feb 17. PMID 16361250
  4. Metabolic, Organoleptic and Transcriptomic Impact of Saccharomyces cerevisiae Genes Involved in the Biosynthesis of Linear and Substituted Esters. Marullo P, et al. Int J Mol Sci, 2021 Apr 14. PMID 33919724, Free PMC Article
  5. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables monoacylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in medium-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative carboxylic ester hydrolase
NP_013937.1
  • Monoacylglycerol and triacylglycerol lipase; MAG lipase with preference for palmitoyl-MAG; TAG lipase involved in TAG catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif (GXSXG); similar to acyltransferases, Eeb1p, Eht1p, and human ABHD1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    687516..688865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182717.1 → NP_013937.1  TPA: putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013937.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W035, Q03649
    UniProtKB/TrEMBL
    A6ZMS2, B3LM98, C7GRE1, C8ZF74, N1NYL9
    Conserved Domains (1) summary
    COG0429
    Location:33 → 433
    YheT; Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03649.1

Gene LinkOut

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