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EFR3 Efr3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855252, updated on 9-Dec-2024

Summary

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Official Symbol
EFR3
Official Full Name
Efr3p
Primary source
SGD:S000004825
Locus tag
YMR212C
See related
AllianceGenome:SGD:S000004825; FungiDB:YMR212C; VEuPathDB:YMR212C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein localization to plasma membrane. Located in plasma membrane. Used to study autism spectrum disorder. Orthologous to human EFR3A (EFR3 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EFR3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (690695..693043, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative carboxylic ester hydrolase Neighboring gene Dml1p Neighboring gene Cef1p Neighboring gene Scj1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rare deleterious mutations of the gene EFR3A in autism spectrum disorders. Gupta AR, et al. Mol Autism, 2014. PMID 24860643, Free PMC Article
  2. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Wu X, et al. Dev Cell, 2014 Jan 13. PMID 24360784, Free PMC Article
  3. Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. Baird D, et al. J Cell Biol, 2008 Dec 15. PMID 19075114, Free PMC Article
  4. A heat-sensitive Osh protein controls PI4P polarity. Omnus DJ, et al. BMC Biol, 2020 Mar 13. PMID 32169085, Free PMC Article
  5. Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Lenburg ME, et al. Genetics, 2001 Jan. PMID 11139490, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Efr3 C terminus phosphorylation regulates phosphatidylinositol 4-kinase complex assembly and plasma membrane targeting.
    Title: Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex.
  2. Ypp1 and Efr3 are required for the formation and architecture of Stt4 PIK patches and ultimately plasma membrane-based PtdIns4P signaling.
    Title: Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Efr3p
NP_013939.1
  • Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at plasma membrane; recruited to plasma membrane via conserved basic patch near N-terminus; exhibits synthetic lethal genetic interactions with PHO85; mutations in human homolog EFR3A implicated in autism spectrum disorders

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    690695..693043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182719.1 → NP_013939.1  TPA: Efr3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013939.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W037, Q03653
    UniProtKB/TrEMBL
    B3LMA0, C7GRD9, C8ZF76
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03653.1

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