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BCH1 exomer complex subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 855277, updated on 9-Dec-2024

Summary

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Official Symbol
BCH1
Official Full Name
exomer complex subunit
Primary source
SGD:S000004850
Locus tag
YMR237W
See related
AllianceGenome:SGD:S000004850; FungiDB:YMR237W; VEuPathDB:YMR237W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small GTPase binding activity. Involved in Golgi to plasma membrane transport and chitin biosynthetic process. Part of exomer complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BCH1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (743749..745923)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RNA1 Neighboring gene chromatin modification protein Neighboring gene putative mannan endo-1,6-alpha-mannosidase Neighboring gene tRNA-Arg

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The exomer cargo adaptor features a flexible hinge domain. Richardson BC, et al. Structure, 2013 Mar 5. PMID 23395181, Free PMC Article
  2. Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor. Paczkowski JE, et al. Dev Cell, 2014 Sep 8. PMID 25203211, Free PMC Article
  3. The complex interactions of Chs5p, the ChAPs, and the cargo Chs3p. Rockenbauch U, et al. Mol Biol Cell, 2012 Nov. PMID 23015758, Free PMC Article
  4. Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. Wang CW, et al. J Cell Biol, 2006 Sep 25. PMID 17000877, Free PMC Article
  5. The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast. Barfield RM, et al. Mol Biol Cell, 2009 Dec. PMID 19812245, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi to plasma membrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chitin biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of exomer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exomer complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exomer complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exomer complex subunit
NP_013964.1
  • Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    743749..745923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182744.1 → NP_013964.1  TPA: exomer complex subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013964.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W063, Q05029
    UniProtKB/TrEMBL
    C7GRB4, C8ZFA2, N1P0K7
    Conserved Domains (1) summary
    pfam09295
    Location:85 → 511
    ChAPs; ChAPs (Chs5p-Arf1p-binding proteins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05029.1

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