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PPA2 inorganic diphosphatase PPA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855309, updated on 9-Dec-2024

Summary

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Official Symbol
PPA2
Official Full Name
inorganic diphosphatase PPA2
Primary source
SGD:S000004880
Locus tag
YMR267W
See related
AllianceGenome:SGD:S000004880; FungiDB:YMR267W; VEuPathDB:YMR267W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
IPP2
Summary
Enables inorganic diphosphate phosphatase activity. Involved in aerobic respiration. Located in mitochondrion. Used to study dilated cardiomyopathy and myocarditis. Orthologous to human PPA1 (inorganic pyrophosphatase 1) and PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PPA2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (801772..802704)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rsn1p Neighboring gene U6 snRNP complex subunit PRP24 Neighboring gene Tma23p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a mitochondrial inorganic pyrophosphatase in Saccharomyces cerevisiae. Lundin M, et al. Biochim Biophys Acta, 1992 Jan 16. PMID 1309654
  2. Interactions of calcium and magnesium with the mitochondrial inorganic pyrophosphatase from Saccharomyces cerevisiae. Uribe S, et al. Eur J Biochem, 1993 Oct 15. PMID 8223607
  3. Studies on the utilization of inorganic pyrophosphate by different metabolic systems in yeast mitochondria. Pereira-da-Silva L, et al. Braz J Med Biol Res, 1993 Apr. PMID 8298510
  4. Inorganic pyrophosphate gives a membrane potential in yeast mitochondria, as measured with the permeant cation tetraphenylphosphonium. Pereira-da-Silva L, et al. Arch Biochem Biophys, 1993 Aug 1. PMID 8394052
  5. Glutamic acid 472 and lysine 480 of the sodium pump alpha 1 subunit are essential for activity. Their conservation in pyrophosphatases suggests their involvement in recognition of ATP phosphates. Scheiner-Bobis G, et al. Biochemistry, 1999 Jul 20. PMID 10413494

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inorganic diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate-containing compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
inorganic diphosphatase PPA2
NP_013994.1
  • Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    801772..802704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182774.1 → NP_013994.1  TPA: inorganic diphosphatase PPA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W093, P28239
    UniProtKB/TrEMBL
    B3LMF4, B5VQ31, C7GR87, C8ZFD3
    Conserved Domains (1) summary
    cl00217
    Location:6 → 271
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28239.1

Gene LinkOut

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