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FET4 Fet4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855369, updated on 9-Dec-2024

Summary

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Official Symbol
FET4
Official Full Name
Fet4p
Primary source
SGD:S000004938
Locus tag
YMR319C
See related
AllianceGenome:SGD:S000004938; FungiDB:YMR319C; VEuPathDB:YMR319C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables copper ion transmembrane transporter activity and iron ion transmembrane transporter activity. Involved in protein maturation by copper ion transfer and transition metal ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FET4 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (912880..914538, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NADP-dependent alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae. Dix DR, et al. J Biol Chem, 1994 Oct 21. PMID 7929320
  2. Characterization of the FET4 protein of yeast. Evidence for a direct role in the transport of iron. Dix D, et al. J Biol Chem, 1997 May 2. PMID 9115232
  3. A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Eide D, et al. Proc Natl Acad Sci U S A, 1996 May 28. PMID 8643627, Free PMC Article
  4. Metal transporters that contribute copper to metallochaperones in Saccharomyces cerevisiae. Portnoy ME, et al. Mol Genet Genomics, 2001 Jul. PMID 11523804
  5. Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes. Smyth DJ, et al. J Biol Chem, 2006 Jan 27. PMID 16267047, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in copper ion import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in iron ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by copper ion transfer IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in zinc ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Fet4p
NP_014052.1
  • Low-affinity Fe(II) transporter of the plasma membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    912880..914538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182832.1 → NP_014052.1  TPA: Fet4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014052.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0E7, P40988
    UniProtKB/TrEMBL
    A6ZN37, B3LMK8, N1NXV2
    Conserved Domains (2) summary
    COG5478
    Location:207 → 381
    Fet4; Low affinity Fe/Cu permease [Inorganic ion transport and metabolism]
    cl12096
    Location:454 → 519
    Iron_permease; Low affinity iron permease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40988.2

Gene LinkOut

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