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DDI2 cyanamide hydratase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855381, updated on 4-Jan-2025

Summary

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Official Symbol
DDI2
Official Full Name
cyanamide hydratase
Primary source
SGD:S000005279
Locus tag
YNL335W
See related
AllianceGenome:SGD:S000005279; FungiDB:YNL335W; VEuPathDB:YNL335W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DDI3
Summary
Enables cyanamide hydratase activity. Involved in cyanamide metabolic process. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See DDI2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (11452..12129)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Y' element ATP-dependent helicase protein 1 copy 6 Neighboring gene Cos1p Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Ddi2, a highly inducible detoxifying metalloenzyme from Saccharomyces cerevisiae. Li J, et al. J Biol Chem, 2019 Jul 5. PMID 31152065, Free PMC Article
  2. Two duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamide. Li J, et al. J Biol Chem, 2015 May 15. PMID 25847245, Free PMC Article
  3. Transcriptomic and phenotypic analysis of the effects of T-2 toxin on Saccharomyces cerevisiae: evidence of mitochondrial involvement. Jossé L, et al. FEMS Yeast Res, 2011 Feb. PMID 21114626
  4. Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Fu Y, et al. Cell, 2008 May 16. PMID 18485869
  5. Global response of Saccharomyces cerevisiae to an alkylating agent. Jelinsky SA, et al. Proc Natl Acad Sci U S A, 1999 Feb 16. PMID 9990050, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDI2/3 genes protect host cells from cyanamide toxicity.
    Title: Two duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamide.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyanamide hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyanamide hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cyanamide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
cyanamide hydratase
NP_014064.1
  • Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    11452..12129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183173.1 → NP_014064.1  TPA: cyanamide hydratase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014064.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTG9, P0CH63, P0CH64, P43543
    UniProtKB/TrEMBL
    B3LPG7, B5VQ88, C8ZBV9, N1P6I3
    Conserved Domains (1) summary
    TIGR03401
    Location:2 → 224
    cyanamide_fam; HD domain protein, cyanamide hydratase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CH63.1
P0CH64.1

Gene LinkOut

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Molecular Biology Databases
Research Materials