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SKP2 putative SCF ubiquitin ligase complex subunit SKP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855405, updated on 9-Dec-2024

Summary

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Official Symbol
SKP2
Official Full Name
putative SCF ubiquitin ligase complex subunit SKP2
Primary source
SGD:S000005255
Locus tag
YNL311C
See related
AllianceGenome:SGD:S000005255; FungiDB:YNL311C; VEuPathDB:YNL311C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein-macromolecule adaptor activity. Involved in protein catabolic process and regulation of sulfur amino acid metabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SKP2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (49397..51688, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat-containing protein EMW1 Neighboring gene Rfa2p Neighboring gene Zim17p Neighboring gene Stb1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new Saccharomyces cerevisiae variants of the MET2 and SKP2 genes controlling the sulfur assimilation pathway and the production of undesirable sulfur compounds during alcoholic fermentation. Noble J, et al. Microb Cell Fact, 2015 May 8. PMID 25947166, Free PMC Article
  2. Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction. Singh R, et al. Bioorg Med Chem Lett, 2015 Nov 15. PMID 26463131
  3. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224
  4. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Patton EE, et al. Trends Genet, 1998 Jun. PMID 9635407
  5. A novel mechanism regulates H(2) S and SO(2) production in Saccharomyces cerevisiae. Yoshida S, et al. Yeast, 2011 Feb. PMID 20936605

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of sulfur amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative SCF ubiquitin ligase complex subunit SKP2
NP_014088.1
  • F-box hypothetical protein; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    49397..51688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183149.1 → NP_014088.1  TPA: putative SCF ubiquitin ligase complex subunit SKP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014088.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0N4, P42843, Q6B2L9
    UniProtKB/TrEMBL
    C7GWQ8, G2WLF8, N1NXF4
    Conserved Domains (1) summary
    pfam12937
    Location:60 → 100
    F-box-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42843.1

Gene LinkOut

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