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PCL1 Pcl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855427, updated on 9-Dec-2024

Summary

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Official Symbol
PCL1
Official Full Name
Pcl1p
Primary source
SGD:S000005233
Locus tag
YNL289W
See related
AllianceGenome:SGD:S000005233; FungiDB:YNL289W; VEuPathDB:YNL289W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HCS26
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of macroautophagy; regulation of establishment or maintenance of cell polarity; and septin ring organization. Located in incipient cellular bud site and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PCL1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (87897..88736)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mid1p Neighboring gene replication factor C subunit 3 Neighboring gene ncRNA Neighboring gene CCR4-NOT core subunit CAF40

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro. Andrews BJ, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1465410, Free PMC Article
  2. SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1. Fernandez-Sarabia MJ, et al. Genes Dev, 1992 Dec. PMID 1334024
  3. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Ogas J, et al. Cell, 1991 Sep 6. PMID 1832336
  4. CDK-mediated Yku80 Phosphorylation Regulates the Balance Between Non-homologous End Joining (NHEJ) and Homologous Directed Recombination (HDR). Carballar R, et al. J Mol Biol, 2020 Dec 4. PMID 33217428
  5. The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast. Ros-Carrero C, et al. EMBO Rep, 2024 Feb. PMID 38233717, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment or maintenance of cell polarity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in septin ring organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pcl1p
NP_014110.1
  • Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    87897..88736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183127.1 → NP_014110.1  TPA: Pcl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014110.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Q4, P24867
    UniProtKB/TrEMBL
    A6ZSI9, B3LPC7, B5VQC8, C7GS52, C8ZGN2, G2WLH8, N1NWW7
    Conserved Domains (1) summary
    cd20557
    Location:54 → 149
    CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24867.1

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