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PDR17 phosphatidylinositol transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 855457, updated on 9-Dec-2024

Summary

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Official Symbol
PDR17
Official Full Name
phosphatidylinositol transporter
Primary source
SGD:S000005208
Locus tag
YNL264C
See related
AllianceGenome:SGD:S000005208; FungiDB:YNL264C; VEuPathDB:YNL264C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ISS1; SFH4
Summary
Enables phosphatidylinositol transfer activity and sterol binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; phospholipid metabolic process; and regulation of phospholipid biosynthetic process. Located in cell periphery; cytosol; and endosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PDR17 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (145563..146615, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 1-phosphatidylinositol 4-kinase Neighboring gene Ist1p Neighboring gene protein transporter YIF1 Neighboring gene DNA polymerase epsilon catalytic subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14. Wu WI, et al. J Biol Chem, 2000 May 12. PMID 10799527
  2. Yeast Sec14-like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol. Šťastný D, et al. FEBS Lett, 2023 Feb. PMID 36482167
  3. The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. Šimová Z, et al. Yeast, 2013 Jun. PMID 23606207
  4. Phosphatidylserine-induced dissociation of the heterodimeric PstB2p/Pbi1p complex in yeast phosphatidylserine trafficking system. Cho HJ, et al. Biochem Biophys Res Commun, 2019 Sep 17. PMID 31351588
  5. Yeast phosphatidylinositol transfer protein Pdr17 does not require high affinity phosphatidylinositol binding for its cellular function. Pevalová Z, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Oct. PMID 31302248

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PstB2p (PDR17) forms a homodimer but exists as a 1:1 heterodimer in the presence of Pbi1p. Phosphatidylserine binding to PstB2p triggers the dissociation of the PstB2p-Pbi1p complex.
    Title: Phosphatidylserine-induced dissociation of the heterodimeric PstB2p/Pbi1p complex in yeast phosphatidylserine trafficking system.
  2. Mutated phosphatidylinositol (PI) transfer protein Pdr17E237A, K269A is defective in high affinity PI binding. Pdr17p binds a sterol in addition to PI in an assay using permeabilized cells. PI binding defective Pdr17E237A, K269A retains the ability to transfer PI in vitro.
    Title: Yeast phosphatidylinositol transfer protein Pdr17 does not require high affinity phosphatidylinositol binding for its cellular function.
  3. model predicts that this process involves an acceptor membrane complex containing the C2 domains of Psd2p, PstB2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane
    Title: An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.
  4. Overexpression of PDR17 complemented the azole susceptible phenotype of the pdr16Delta strain and corrected the enhanced sterol alterations in pdr16Delta cells in the presence of azoles.
    Title: The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol transfer activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphatidylinositol transfer activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phosphatidylglycerol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylserine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phospholipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylcholine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol transporter
NP_014135.1
  • Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    145563..146615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183102.1 → NP_014135.1  TPA: phosphatidylinositol transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0S9, P53844
    UniProtKB/TrEMBL
    A6ZRH9, B3LPA4, B5VQE8, C7GP98, C8ZFX5, G2WLK1, N1NXZ0
    Conserved Domains (2) summary
    pfam00650
    Location:146 → 291
    CRAL_TRIO; CRAL/TRIO domain
    pfam03765
    Location:49 → 115
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53844.1

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