NAR1 iron-sulfur cluster assembly protein NAR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: NAR1
Official Full Name: iron-sulfur cluster assembly protein NAR1
Primary source: SGD:S000005184
Locus tag: YNL240C
See related: AllianceGenome:SGD:S000005184; FungiDB:YNL240C; VEuPathDB:YNL240C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ferredoxin hydrogenase activity. Involved in iron-sulfur cluster assembly. Located in cytosol and membrane. Orthologous to several human genes including CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See NAR1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (198502..199977, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A deletion of NAR1 caused a similar increased sensitivity to oxygen.
Title: [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode.
Nar1 holds two iron-sulfur (Fe/S) clusters at conserved amino- and carboxyl-terminal cysteine motifs, both of which are essential for Nar1 function and cell viability.
Title: Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1.
Results suggest that Nar1p represents a crucial, novel component of the emerging cytosolic iron/sulfur protein assembly machinery that catalyses an essential and ancient process in eukaryotes.
Title: The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables ferredoxin hydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: iron-sulfur cluster assembly protein NAR1

NP_014159.1

Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

198502..199977 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183078.1 → NP_014159.1 TPA: iron-sulfur cluster assembly protein NAR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014159.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0V3, P23503

UniProtKB/TrEMBL

B3LP79, B5VQG9, C7GPC0, N1NY14

Conserved Domains (1) summary

COG4624
Location:21 → 484

Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]