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RPL42A ribosomal 60S subunit protein L42A [ Saccharomyces cerevisiae S288C ]

Gene ID: 855560, updated on 9-Dec-2024

Summary

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Official Symbol
RPL42A
Official Full Name
ribosomal 60S subunit protein L42A
Primary source
SGD:S000005106
Locus tag
YNL162W
See related
AllianceGenome:SGD:S000005106; FungiDB:YNL162W; VEuPathDB:YNL162W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL36A (ribosomal protein L36a) and RPL36AL (ribosomal protein L36a like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPL42A in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (331322..332154)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene GTPase RIA1 Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase CBK1 Neighboring gene Ygp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site saturation mutagenesis of ribosomal protein L42 at 56th residue and application as a consecutive selection marker for cycloheximide resistance in yeast. Bae JH, et al. FEMS Microbiol Lett, 2018 Apr 1. PMID 29566228
  2. The primary structure of protein 44 from the large subunit of yeast ribosomes. Itoh T, et al. FEBS Lett, 1978 Dec 15. PMID 365584
  3. Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Pellegrino S, et al. Nucleic Acids Res, 2019 Apr 8. PMID 30759226, Free PMC Article
  4. Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. Malyutin AG, et al. EMBO J, 2017 Apr 3. PMID 28179369, Free PMC Article
  5. mRNA with Mammalian Codon Bias Accumulates in Yeast Mutants with Constitutive Stress Granules. Kozlova NV, et al. Int J Mol Sci, 2020 Feb 12. PMID 32059599, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The 56th residue of(Rpl42a determines the sensitivity of yeast cells to the antibiotic cycloheximide.
    Title: Site saturation mutagenesis of ribosomal protein L42 at 56th residue and application as a consecutive selection marker for cycloheximide resistance in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cycloheximide IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L42A
NP_014237.2
  • Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    331322..332154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183000.1 → NP_014237.2  TPA: ribosomal 60S subunit protein L42A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014237.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL90, P02405, P0CX27, P0CX28
    UniProtKB/TrEMBL
    A6ZRS2, B3LP17, C8Z9T8, G2WFL4, N1P172
    Conserved Domains (1) summary
    PTZ00157
    Location:1 → 86
    PTZ00157; 60S ribosomal protein L36a; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX27.1
P0CX28.1

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