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RHO2 Rho family GTPase RHO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855634, updated on 9-Dec-2024

Summary

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Official Symbol
RHO2
Official Full Name
Rho family GTPase RHO2
Primary source
SGD:S000005034
Locus tag
YNL090W
See related
AllianceGenome:SGD:S000005034; FungiDB:YNL090W; VEuPathDB:YNL090W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Located in membrane. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A); RHOB (ras homolog family member B); and RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RHO2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (456565..457143)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Nst1p Neighboring gene DNA topoisomerase 2 Neighboring gene tricalbin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell polarity and morphogenesis in budding yeast. Madden K, et al. Annu Rev Microbiol, 1998. PMID 9891811
  2. Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Madaule P, et al. Proc Natl Acad Sci U S A, 1987 Feb. PMID 3543936, Free PMC Article
  3. MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae. Desrivières S, et al. J Biol Chem, 1998 Jun 19. PMID 9624178
  4. RHO gene products, putative small GTP-binding proteins, are important for activation of the CAL1/CDC43 gene product, a protein geranylgeranyltransferase in Saccharomyces cerevisiae. Qadota H, et al. Yeast, 1992 Sep. PMID 1441750
  5. Dissecting the architecture of a quantitative trait locus in yeast. Steinmetz LM, et al. Nature, 2002 Mar 21. PMID 11907579

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in establishment of cell polarity TAS
Traceable Author Statement
more info
 PubMed 
involved_in fungal-type cell wall organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule-based process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho family GTPase RHO2
NP_014309.3
  • Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    456565..457143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182928.3 → NP_014309.3  TPA: Rho family GTPase RHO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014309.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W190, P06781, Q45TZ2
    UniProtKB/TrEMBL
    A6ZRZ1, B3LNU8, C7GUN9, C8ZGE1, G2WM15, N1NZF7, Q7LM87, Q7LMA1
    Conserved Domains (1) summary
    cd04129
    Location:7 → 191
    Rho2; Ras homology family 2 (Rho2) of small guanosine triphosphatases (GTPases)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06781.2

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