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ARP5 Arp5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855665, updated on 4-Jan-2025

Summary

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Official Symbol
ARP5
Official Full Name
Arp5p
Primary source
SGD:S000005004
Locus tag
YNL059C
See related
AllianceGenome:SGD:S000005004; FungiDB:YNL059C; VEuPathDB:YNL059C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Involved in chromatin remodeling. Part of Ino80 complex. Is active in nucleus. Orthologous to human ACTR5 (actin related protein 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ARP5 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (512668..514935, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA 1-methyladenosine methyltransferase subunit GCD10 Neighboring gene rRNA (cytosine-C5-)-methyltransferase NOP2 Neighboring gene uncharacterized protein Neighboring gene Oca2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near +1 nucleosomes. Yen K, et al. Cell, 2013 Sep 12. PMID 24034248, Free PMC Article
  2. Actin-related proteins (Arps): conformational switches for chromatin-remodeling machines? Boyer LA, et al. Bioessays, 2000 Jul. PMID 10878579
  3. A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function. Hsieh LJ, et al. Mol Cell, 2022 Jun 2. PMID 35597239, Free PMC Article
  4. The Ino80 complex prevents invasion of euchromatin into silent chromatin. Xue Y, et al. Genes Dev, 2015 Feb 15. PMID 25691465, Free PMC Article
  5. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. van Attikum H, et al. Cell, 2004 Dec 17. PMID 15607975

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ino80 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membraneless organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arp5p
NP_014339.1
  • Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    512668..514935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182898.1 → NP_014339.1  TPA: Arp5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1C0, P53946
    UniProtKB/TrEMBL
    A6ZS20, G2WM45, N1NXK3
    Conserved Domains (3) summary
    COG5277
    Location:33 → 358
    COG5277; Actin-related protein [Cytoskeleton]
    PRK00409
    Location:292 → 428
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    cl17037
    Location:536 → 748
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53946.1

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