U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NCE103 carbonate dehydratase NCE103 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855692, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
NCE103
Official Full Name
carbonate dehydratase NCE103
Primary source
SGD:S000004981
Locus tag
YNL036W
See related
AllianceGenome:SGD:S000004981; FungiDB:YNL036W; VEuPathDB:YNL036W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NCE3
Summary
Enables carbonate dehydratase activity. Involved in cellular response to carbon dioxide and cellular response to oxidative stress. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NCE103 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (559814..560479)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI15 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH1 Neighboring gene tRNA-Thr Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deletion of the carbonic anhydrase-like gene NCE103 of the yeast Saccharomyces cerevisiae causes an oxygen-sensitive growth defect. Götz R, et al. Yeast, 1999 Jul. PMID 10407265
  2. Complementation of the yeast deletion mutant DeltaNCE103 by members of the beta class of carbonic anhydrases is dependent on carbonic anhydrase activity rather than on antioxidant activity. Clark D, et al. Biochem J, 2004 May 1. PMID 15096093, Free PMC Article
  3. The gene NCE103 (YNL036w) from Saccharomyces cerevisiae encodes a functional carbonic anhydrase and its transcription is regulated by the concentration of inorganic carbon in the medium. Amoroso G, et al. Mol Microbiol, 2005 Apr. PMID 15813743
  4. Carbonic anhydrase (Nce103p): an essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure. Aguilera J, et al. Biochem J, 2005 Oct 15. PMID 15948716, Free PMC Article
  5. Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions. Isik S, et al. Bioorg Med Chem Lett, 2008 Dec 15. PMID 18993072

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3.
    Title: Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3.
  2. Elevated CO2 concentrations are required even under conditions where CO2 is produced at high rates by fermentative sugar metabolism in nce103 null S. cerevisiae mutants.
    Title: Carbonic anhydrase (Nce103p): an essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbon utilization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to carbon dioxide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
carbonate dehydratase NCE103
NP_014362.3
  • Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    559814..560479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182875.3 → NP_014362.3  TPA: carbonate dehydratase NCE103 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014362.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1E3, P53615
    UniProtKB/TrEMBL
    B3LNP8, C7GLW4, C8ZFW1, G2WM67, N1NY21
    Conserved Domains (1) summary
    cd00883
    Location:25 → 212
    beta_CA_cladeA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53615.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools