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SWM2 Swm2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855738, updated on 9-Dec-2024

Summary

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Official Symbol
SWM2
Official Full Name
Swm2p
Primary source
SGD:S000005287
Locus tag
YNR004W
See related
AllianceGenome:SGD:S000005287; FungiDB:YNR004W; VEuPathDB:YNR004W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in 7-methylguanosine cap hypermethylation and tRNA processing. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SWM2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (635943..636383)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative ammonium permease ATO2 Neighboring gene DNA-directed RNA polymerase III subunit C34 Neighboring gene ESCRT-0 subunit protein VPS27 Neighboring gene Atg3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Boon KL, et al. Sci Rep, 2015 Jun 15. PMID 26074133, Free PMC Article
  2. Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p). Boon KL, et al. FEBS Lett, 2010 Aug 4. PMID 20621096
  3. Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. Heininger AU, et al. RNA Biol, 2016. PMID 26821976, Free PMC Article
  4. Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing. Chang J, et al. RNA, 2010 May. PMID 20360394, Free PMC Article
  5. Precursors of tRNAs are stabilized by methylguanosine cap structures. Ohira T, et al. Nat Chem Biol, 2016 Aug. PMID 27348091

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Self-association of Tgs1p and its catalytic activity were prerequisite to bypass the requirement for its accessory factor Swm2p for efficient pre-rRNA processing and snRNA trimethylation.
    Title: Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine cap hypermethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Swm2p
NP_014401.1
  • Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    635943..636383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183181.1 → NP_014401.1  TPA: Swm2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014401.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZS79, B3LPN5, C7GLQ0, C8ZFN1, D6W1I0, P40342, Q540B3
    UniProtKB/TrEMBL
    G2WL62, N1NZN5
    Conserved Domains (1) summary
    pfam17083
    Location:14 → 144
    Swm2; Nucleolar protein Swm2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40342.1

Gene LinkOut

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