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PHO91 Pho91p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855747, updated on 9-Dec-2024

Summary

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Official Symbol
PHO91
Official Full Name
Pho91p
Primary source
SGD:S000005296
Locus tag
YNR013C
See related
AllianceGenome:SGD:S000005296; FungiDB:YNR013C; VEuPathDB:YNR013C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glycerol-3-phosphate transmembrane transporter activity and phosphate transmembrane transporter activity. Involved in several processes, including glycerol-3-phosphate transmembrane transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A1 (solute carrier family 13 member 1); SLC13A2 (solute carrier family 13 member 2); and SLC13A4 (solute carrier family 13 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PHO91 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (649028..651712, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DEAH-box RNA-dependent ATPase PRP2 Neighboring gene uridine kinase URK1 Neighboring gene uncharacterized protein Neighboring gene tRNA-dihydrouridine(20) synthase (NAD(+))

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Auesukaree C, et al. Biochem Biophys Res Commun, 2003 Jul 11. PMID 12821119
  2. Inhibition of the protein kinase A alters the degradation of the high-affinity phosphate transporter Pho84 in Saccharomyces cerevisiae. Mouillon JM, et al. Curr Genet, 2005 Oct. PMID 16160831
  3. The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae. Estrella LA, et al. J Biol Chem, 2008 Feb 29. PMID 18165238
  4. Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae. Hürlimann HC, et al. Mol Biol Cell, 2007 Nov. PMID 17804816, Free PMC Article
  5. Phosphate transport and sensing in Saccharomyces cerevisiae. Wykoff DD, et al. Genetics, 2001 Dec. PMID 11779791, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pho91 serves as a vacuolar phosphate transporter that exports phosphate from the vacuolar lumen to the cytosol
    Title: Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycerol-3-phosphate transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glycerol-3-phosphate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerol-3-phosphate transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycerol-3-phosphate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphate transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Pho91p
NP_014410.3
  • Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    649028..651712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183190.3 → NP_014410.3  TPA: Pho91p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014410.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1I8, P27514
    UniProtKB/TrEMBL
    B3LPM9, C7GLP2, C8ZFP0, N1NZP5
    Conserved Domains (2) summary
    COG5408
    Location:1 → 262
    COG5408; SPX domain-containing protein [Signal transduction mechanisms]
    cd01115
    Location:460 → 889
    SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27514.2

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