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SEC12 Sar family guanine nucleotide exchange factor SEC12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855760, updated on 9-Dec-2024

Summary

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Official Symbol
SEC12
Official Full Name
Sar family guanine nucleotide exchange factor SEC12
Primary source
SGD:S000005309
Locus tag
YNR026C
See related
AllianceGenome:SGD:S000005309; FungiDB:YNR026C; VEuPathDB:YNR026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SED2
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in regulation of COPII vesicle coating. Located in Golgi apparatus and endoplasmic reticulum. Used to study autism spectrum disorder; cranioectodermal dysplasia; and intellectual disability. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEC12 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (673274..674689, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Snf12p Neighboring gene Mpp6p Neighboring gene putative pyridoxal kinase BUD17 Neighboring gene peptidylprolyl isomerase family protein CPR8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, purification, and assay of Sec12p: a Sar1p-specific GDP dissociation stimulator. Barlowe C, et al. Methods Enzymol, 1995. PMID 8583945
  2. Purification, crystallization and preliminary X-ray diffraction analysis of the yeast Sec12Deltap protein, a guanine nucleotide-exchange factor involved in vesicle transport. Dumon-Seignovert L, et al. Acta Crystallogr D Biol Crystallogr, 2001 Jun. PMID 11375521
  3. The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as beta-propellers. Chardin P, et al. FEBS Lett, 2002 Aug 14. PMID 12163183
  4. A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast. Nakano A, et al. J Cell Biol, 1988 Sep. PMID 3047151, Free PMC Article
  5. SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER. Barlowe C, et al. Nature, 1993 Sep 23. PMID 8377826

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for the initiation of COPII vesicle biogenesis.
    Title: Structural basis for the initiation of COPII vesicle biogenesis.
  2. The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
    Title: The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of COPII vesicle coating IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sar family guanine nucleotide exchange factor SEC12
NP_014423.1
  • Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    673274..674689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183203.1 → NP_014423.1  TPA: Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014423.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1K0, P11655
    UniProtKB/TrEMBL
    A6ZS99, B3LPL8, C7GLN2, C8ZFQ3, G2WL82, N1P4R6
    Conserved Domains (2) summary
    COG2319
    Location:79 → 335
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:177 → 212
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11655.1

Gene LinkOut

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