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ARC35 Arc35p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855771, updated on 9-Dec-2024

Summary

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Official Symbol
ARC35
Official Full Name
Arc35p
Primary source
SGD:S000005318
Locus tag
YNR035C
See related
AllianceGenome:SGD:S000005318; FungiDB:YNR035C; VEuPathDB:YNR035C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
END9
Summary
Enables calmodulin binding activity and molecular adaptor activity. Involved in cytoskeleton organization; protein localization to cell cortex; and receptor-mediated endocytosis. Located in cytosol. Part of Arp2/3 protein complex. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ARC35 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (693019..694047, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sol1p Neighboring gene Ego4p Neighboring gene putative mitochondrial 37S ribosomal protein MRPS12 Neighboring gene mitochondrial 37S ribosomal protein RSM19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization. Han X, et al. Cell Rep, 2023 Jun 27. PMID 37269287
  2. Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Schaerer-Brodbeck C, et al. Mol Biol Cell, 2000 Apr. PMID 10749918, Free PMC Article
  3. Saccharomyces cerevisiae Arc35p works through two genetically separable calmodulin functions to regulate the actin and tubulin cytoskeletons. Schaerer-Brodbeck C, et al. J Cell Sci, 2000 Feb. PMID 10639338
  4. GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Gandhi M, et al. Curr Biol, 2010 May 11. PMID 20362448, Free PMC Article
  5. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cortical patch organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Arc35p
NP_014433.1
  • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    693019..694047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183212.1 → NP_014433.1  TPA: Arc35p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014433.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1L1, P53731
    UniProtKB/TrEMBL
    A6ZSB0, B3LPK7, B5VR64, C7GLM1, C8ZFR4, G2WL93, N1NZR7
    Conserved Domains (1) summary
    pfam04045
    Location:56 → 316
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53731.1

Gene LinkOut

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