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FRE4 ferric-chelate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855797, updated on 4-Jan-2025

Summary

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Official Symbol
FRE4
Official Full Name
ferric-chelate reductase
Primary source
SGD:S000005343
Locus tag
YNR060W
See related
AllianceGenome:SGD:S000005343; FungiDB:YNR060W; VEuPathDB:YNR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferric-chelate reductase activity. Involved in siderophore transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See FRE4 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (739951..742110)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene adenosylmethionine-8-amino-7-oxononanoate transaminase Neighboring gene putative alpha-1,3-mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene Pul3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. Martins LJ, et al. J Biol Chem, 1998 Sep 11. PMID 9726978
  2. Insufficiency of copper ion homeostasis causes freeze-thaw injury of yeast cells as revealed by indirect gene expression analysis. Takahashi S, et al. Appl Environ Microbiol, 2009 Nov. PMID 19749072, Free PMC Article
  3. The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. Yun CW, et al. J Biol Chem, 2001 Mar 30. PMID 11120744
  4. Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. Herst PM, et al. FEMS Yeast Res, 2008 Sep. PMID 18657191
  5. Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Georgatsou E, et al. Yeast, 1999 May. PMID 10341420

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferric-chelate reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables ferric-chelate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric-chelate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferric-chelate reductase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ferric-chelate reductase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ferric-chelate reductase
NP_014458.1
  • Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    739951..742110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183237.1 → NP_014458.1  TPA: ferric-chelate reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014458.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1N5, P53746
    UniProtKB/TrEMBL
    B3LPI3, C7GIY5, C8ZFT9
    Conserved Domains (3) summary
    cd06186
    Location:428 → 596
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam08030
    Location:530 → 699
    NAD_binding_6; Ferric reductase NAD binding domain
    pfam01794
    Location:276 → 389
    Ferric_reduct; Ferric reductase like transmembrane component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53746.1

Gene LinkOut

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