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SAM3 bifunctional polyamine/amino acid permease SAM3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855854, updated on 9-Dec-2024

Summary

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Official Symbol
SAM3
Official Full Name
bifunctional polyamine/amino acid permease SAM3
Primary source
SGD:S000006195
Locus tag
YPL274W
See related
AllianceGenome:SGD:S000006195; FungiDB:YPL274W; VEuPathDB:YPL274W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables S-adenosyl-L-methionine transmembrane transporter activity; putrescine transmembrane transporter activity; and spermidine transmembrane transporter activity. Involved in S-adenosyl-L-methionine transport; putrescine transport; and spermidine transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SAM3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (22938..24701)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene S-adenosylmethionine-homocysteine S-methyltransferase SAM4 Neighboring gene Pbi1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae. Rouillon A, et al. J Biol Chem, 1999 Oct 1. PMID 10497160
  2. Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae. Uemura T, et al. J Biol Chem, 2007 Mar 9. PMID 17218313
  3. Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2010 Jul 2. PMID 20421295, Free PMC Article
  4. Complementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of Anthracyclines. Brosseau N, et al. PLoS One, 2015. PMID 26177450, Free PMC Article
  5. Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase. Zheng S, et al. Nucleic Acids Res, 2007. PMID 17932050, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-adenosyl-L-methionine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables putrescine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables putrescine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables spermidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spermidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosyl-L-methionine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosyl-L-methionine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
bifunctional polyamine/amino acid permease SAM3
NP_015049.1
  • High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    22938..24701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184088.1 → NP_015049.1  TPA: bifunctional polyamine/amino acid permease SAM3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W396, Q08986, Q7LGU1
    UniProtKB/TrEMBL
    B3LML0, B5VSR5, C8ZIA5
    Conserved Domains (1) summary
    TIGR00913
    Location:74 → 551
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08986.1

Gene LinkOut

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