U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

APM1 Apm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855869, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
APM1
Official Full Name
Apm1p
Primary source
SGD:S000006180
Locus tag
YPL259C
See related
AllianceGenome:SGD:S000006180; FungiDB:YPL259C; VEuPathDB:YPL259C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YAP54
Summary
Predicted to enable clathrin adaptor activity. Involved in Golgi to vacuole transport. Part of AP-1 adaptor complex. Orthologous to several human genes including AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See APM1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (51244..52671, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene fumarase FUM1 Neighboring gene uncharacterized protein Neighboring gene Cub1p Neighboring gene ncRNA Neighboring gene bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Nakayama Y, et al. Eur J Biochem, 1991 Dec 5. PMID 1761056
  2. A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Stepp JD, et al. Mol Biol Cell, 1995 Jan. PMID 7749194, Free PMC Article
  3. Efficient ER exit and vacuole targeting of yeast Sna2p require two tyrosine-based sorting motifs. Renard HF, et al. Traffic, 2010 Jul 1. PMID 20406419
  4. Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast. Kita A, et al. Mol Biol Cell, 2004 Jun. PMID 15047861, Free PMC Article
  5. The clathrin adaptor complex 1 directly binds to a sorting signal in Ste13p to reduce the rate of its trafficking to the late endosome of yeast. Foote C, et al. J Cell Biol, 2006 May 22. PMID 16702232, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role for Apm1 associated with the Golgi/endosome function, thereby affecting various cellular processes, including secretion, cytokinesis, vacuole fusion, and cell integrity; and also calcineurin is involved in these events
    Title: Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Apm1p
NP_015064.1
  • Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    51244..52671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184073.1 → NP_015064.1  TPA: Apm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015064.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3B0, Q00776
    UniProtKB/TrEMBL
    B3LKH3, B5VSS8, C7GSG1, N1NVV9
    Conserved Domains (2) summary
    cd09250
    Location:161 → 471
    AP-1_Mu1_Cterm; C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1
    cd14835
    Location:3 → 143
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00776.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.