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FLC1 flavin adenine dinucleotide transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 855880, updated on 9-Dec-2024

Summary

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Official Symbol
FLC1
Official Full Name
flavin adenine dinucleotide transporter
Primary source
SGD:S000006142
Locus tag
YPL221W
See related
AllianceGenome:SGD:S000006142; FungiDB:YPL221W; VEuPathDB:YPL221W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables FAD transmembrane transporter activity. Involved in several processes, including FAD transport; fungal-type cell wall biogenesis; and protein folding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FLC1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (133043..135424)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Gre1p Neighboring gene Fmp40p Neighboring gene ribosomal 60S subunit protein L1A Neighboring gene Pcl8p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Bop3 confers resistance to methylmercury in Saccharomyces cerevisiae through interaction with other proteins such as Fkh1, Rts1, and Msn2. Hwang GW, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796894
  2. Hypotonic stress-induced calcium signaling in Saccharomyces cerevisiae involves TRP-like transporters on the endoplasmic reticulum membrane. Rigamonti M, et al. Cell Calcium, 2015 Feb. PMID 25573187
  3. A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. Protchenko O, et al. J Biol Chem, 2006 Jul 28. PMID 16717099
  4. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article
  5. Mapping the functional yeast ABC transporter interactome. Snider J, et al. Nat Chem Biol, 2013 Sep. PMID 23831759, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FAD transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in FAD transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in FAD transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flavin adenine dinucleotide transporter
NP_015103.1
  • Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    133043..135424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184035.1 → NP_015103.1  TPA: flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3E9, Q08967
    UniProtKB/TrEMBL
    A6ZW34, B3LKK9, B5VSW0, N1NXX9
    Conserved Domains (2) summary
    pfam06011
    Location:166 → 597
    TRP; Transient receptor potential (TRP) ion channel
    pfam14558
    Location:26 → 161
    TRP_N; ML-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08967.1

Gene LinkOut

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