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PCL8 Pcl8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855882, updated on 9-Dec-2024

Summary

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Official Symbol
PCL8
Official Full Name
Pcl8p
Primary source
SGD:S000006140
Locus tag
YPL219W
See related
AllianceGenome:SGD:S000006140; FungiDB:YPL219W; VEuPathDB:YPL219W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in negative regulation of glycogen biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PCL8 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (136750..138228)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide transporter Neighboring gene ribosomal 60S subunit protein L1A Neighboring gene Arf family GTPase SAR1 Neighboring gene GTPase BMS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p. Wilson WA, et al. FEBS Lett, 2002 Mar 27. PMID 11943203
  2. Overexpression of OLE1 Enhances Cytoplasmic Membrane Stability and Confers Resistance to Cadmium in Saccharomyces cerevisiae. Fang Z, et al. Appl Environ Microbiol, 2017 Jan 1. PMID 27793829, Free PMC Article
  3. Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. Tan YS, et al. J Biol Chem, 2003 Jan 3. PMID 12407105
  4. Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis. Bar-Yosef H, et al. Sci Rep, 2017 Jul 18. PMID 28720834, Free PMC Article
  5. The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p. Wang Z, et al. FEBS Lett, 2001 Oct 12. PMID 11602261

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glycogen biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pcl8p
NP_015105.1
  • Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    136750..138228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184033.1 → NP_015105.1  TPA: Pcl8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015105.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F1, Q08966, Q6B153
    UniProtKB/TrEMBL
    A6ZW36, B3LKL1, B5VSW1, C7GN46, C8ZIG1, G2WNW6, N1NW88
    Conserved Domains (1) summary
    cd20558
    Location:362 → 469
    CYCLIN_ScPCL7-like; cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08966.1

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