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NIP7 ribosome biosynthesis protein NIP7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855890, updated on 9-Dec-2024

Summary

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Official Symbol
NIP7
Official Full Name
ribosome biosynthesis protein NIP7
Primary source
SGD:S000006132
Locus tag
YPL211W
See related
AllianceGenome:SGD:S000006132; FungiDB:YPL211W; VEuPathDB:YPL211W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in assembly of large subunit precursor of preribosome and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleus. Part of preribosome, large subunit precursor. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NIP7 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (153495..154040)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit LEA1 Neighboring gene pseudouridine synthase PUS1 Neighboring gene signal recognition particle subunit SRP72 Neighboring gene aurora kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis. Zanchin NI, et al. Mol Cell Biol, 1997 Sep. PMID 9271378, Free PMC Article
  2. Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA. Coltri PP, et al. Biochemistry, 2007 Dec 11. PMID 18001138
  3. Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Zanchin NI, et al. Mol Cell Biol, 1999 Feb. PMID 9891085, Free PMC Article
  4. Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. Granato DC, et al. FEBS J, 2005 Sep. PMID 16128814
  5. The essential nucleolar yeast protein Nop8p controls the exosome function during 60S ribosomal subunit maturation. Santos MC, et al. PLoS One, 2011. PMID 21747919, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in assembly of large subunit precursor of preribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosome biosynthesis protein NIP7
NP_015113.1
  • Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    153495..154040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184025.1 → NP_015113.1  TPA: ribosome biosynthesis protein NIP7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015113.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F9, Q08962
    UniProtKB/TrEMBL
    A6ZW44, B3LKL9, B5VSW9, C7GN38, C8ZIG8, G2WNX4, N1NXY7
    Conserved Domains (1) summary
    COG1374
    Location:1 → 177
    NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08962.1

Gene LinkOut

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