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DAP1 Dap1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855933, updated on 9-Dec-2024

Summary

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Official Symbol
DAP1
Official Full Name
Dap1p
Primary source
SGD:S000006091
Locus tag
YPL170W
See related
AllianceGenome:SGD:S000006091; FungiDB:YPL170W; VEuPathDB:YPL170W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables heme binding activity. Involved in regulation of ergosterol biosynthetic process. Located in endosome. Orthologous to human PGRMC1 (progesterone receptor membrane component 1) and PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DAP1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (228314..228772)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protoheme IX farnesyltransferase Neighboring gene NADPH dehydrogenase Neighboring gene Mex67p Neighboring gene Mrx4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mallory JC, et al. Mol Cell Biol, 2005 Mar. PMID 15713626, Free PMC Article
  2. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. Hand RA, et al. Eukaryot Cell, 2003 Apr. PMID 12684380, Free PMC Article
  3. Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Thompson AM, et al. Biochemistry, 2007 Dec 18. PMID 18031064, Free PMC Article
  4. Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Ghosh K, et al. Biochemistry, 2005 Dec 20. PMID 16342963, Free PMC Article
  5. Global analysis of the yeast knockout phenome. Turco G, et al. Sci Adv, 2023 May 26. PMID 37235661, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that both wild-type and mutant proteins bind heme in a 1:1 fashion, possessing tight ferric heme affinities and its measured reduction potential was found to be similar to that of other monotyrosinate hemoproteins.
    Title: Measurement of the heme affinity for yeast dap1p, and its importance in cellular function.
  2. Loss of Dap1 is suppressed by elevated levels of Erg11 but not by increased heme biosynthesis.
    Title: Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.
  3. spectroscopic and biochemical characterization of binding to heme
    Title: Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of ergosterol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Dap1p
NP_015155.1
  • Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    228314..228772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183984.1 → NP_015155.1  TPA: Dap1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015155.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3J8, Q12091
    UniProtKB/TrEMBL
    A6ZW83, B3LKQ8, C7GJC1, C8ZIK8, G2WP12, N1NW05
    Conserved Domains (1) summary
    pfam00173
    Location:46 → 108
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12091.1

Gene LinkOut

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