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TGS1 RNA methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855946, updated on 9-Dec-2024

Summary

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Official Symbol
TGS1
Official Full Name
RNA methyltransferase
Primary source
SGD:S000006078
Locus tag
YPL157W
See related
AllianceGenome:SGD:S000006078; FungiDB:YPL157W; VEuPathDB:YPL157W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA methyltransferase activity. Involved in several processes, including RNA processing; nucleologenesis; and regulation of telomere maintenance via telomerase. Located in nucleolus. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TGS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (254814..255761)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pet20p Neighboring gene Aim44p Neighboring gene pheromone-regulated protein PRM4 Neighboring gene Kip2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase. Mouaikel J, et al. Nucleic Acids Res, 2003 Aug 15. PMID 12907733, Free PMC Article
  2. The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology. Colau G, et al. Mol Cell Biol, 2004 Sep. PMID 15340060, Free PMC Article
  3. Characterization of a mimivirus RNA cap guanine-N2 methyltransferase. Benarroch D, et al. RNA, 2009 Apr. PMID 19218551, Free PMC Article
  4. Trimethylguanosine Synthase1 (TGS1) Is Essential for Chilling Tolerance. Gao J, et al. Plant Physiol, 2017 Jul. PMID 28495891, Free PMC Article
  5. Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Boon KL, et al. Sci Rep, 2015 Jun 15. PMID 26074133, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Self-association of Tgs1p and its catalytic activity were prerequisite to bypass the requirement for its accessory factor Swm2p for efficient pre-rRNA processing and snRNA trimethylation.
    Title: Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing.
  2. exploited the synthetic lethal interactions of tgs1Delta and mud2Delta mutations to identify essential structural features of the Tgs1 and Mud2 proteins
    Title: Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing.
  3. methyltransferase Tgs1 has a role in the coordination between telomerase and DNA polymerase for end replication
    Title: Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1.
  4. present a biochemical characterization of the human Tgs1 guanine-N2 methyltransferase reaction and identify individual amino acids required for methyltransferase activity in vitro and in vivo
    Title: Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA cap trimethylguanosine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap trimethylguanosine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine cap hypermethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine cap hypermethylation IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine cap hypermethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleologenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA methyltransferase
NP_015168.1
  • Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    254814..255761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183971.1 → NP_015168.1  TPA: RNA methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015168.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3L1, Q12052
    UniProtKB/TrEMBL
    A6ZW96, C8ZIM1, N1NVF8
    Conserved Domains (1) summary
    pfam09445
    Location:98 → 262
    Methyltransf_15; RNA cap guanine-N2 methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12052.1

Gene LinkOut

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