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KIP2 Kip2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855948, updated on 4-Jan-2025

Summary

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Official Symbol
KIP2
Official Full Name
Kip2p
Primary source
SGD:S000006076
Locus tag
YPL155C
See related
AllianceGenome:SGD:S000006076; FungiDB:YPL155C; VEuPathDB:YPL155C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables microtubule plus end polymerase; plus-end-directed microtubule motor activity; and tubulin binding activity. Involved in microtubule polymerization; negative regulation of microtubule depolymerization; and nuclear migration along microtubule. Located in cortical microtubule plus-end and spindle pole body. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See KIP2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (257216..259336, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA methyltransferase Neighboring gene pheromone-regulated protein PRM4 Neighboring gene proteinase A Neighboring gene serine/threonine/tyrosine protein kinase RAD53

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. Hibbel A, et al. Elife, 2015 Nov 18. PMID 26576948, Free PMC Article
  2. The Kar3p and Kip2p motors function antagonistically at the spindle poles to influence cytoplasmic microtubule numbers. Huyett A, et al. J Cell Sci, 1998 Feb. PMID 9427678
  3. Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Carvalho P, et al. Dev Cell, 2004 Jun. PMID 15177030
  4. Kinesin-related proteins required for assembly of the mitotic spindle. Roof DM, et al. J Cell Biol, 1992 Jul. PMID 1618910, Free PMC Article
  5. Role of Kip2 during early mitosis - impact on spindle pole body separation and chromosome capture. Augustine B, et al. J Cell Sci, 2018 Jun 11. PMID 29739877

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
    Title: The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
  2. The maintenance of Kip2p level and cytoplasmic microtubules lengths during early cell division is important to ensure coordination between spindle pole bodies separation and chromosome capture by kinetochore microtubules.
    Title: Role of Kip2 during early mitosis - impact on spindle pole body separation and chromosome capture.
  3. The budding yeast kinesin Kip2 is a microtubule polymerase and catastrophe inhibitor in vitro that uses its processive motor activity as part of a feedback loop to further promote microtubule growth.
    Title: Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe.
  4. Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2
    Title: Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus end polymerase IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus end polymerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables plus-end-directed microtubule motor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables plus-end-directed microtubule motor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Kip2p
NP_015170.1
  • Kinesin-related motor protein and plus-end directed microtubule (MT) polymerase; involved in mitotic spindle positioning, nuclear migration, microtubule polymerization and inhibition of MT catastrophe; stabilizes microtubules by targeting Bik1p to the MT plus end; Kip2p levels are controlled during the cell cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    257216..259336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183969.1 → NP_015170.1  TPA: Kip2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3L3, P28743
    UniProtKB/TrEMBL
    A6ZW98, B3LKS2, C7GJA7, C8ZIM3, N1NW11
    Conserved Domains (2) summary
    TIGR02168
    Location:445 → 698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01374
    Location:102 → 493
    KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28743.1

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