RPL5 ribosomal 60S subunit protein L5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPL5
Official Full Name: ribosomal 60S subunit protein L5
Primary source: SGD:S000006052
Locus tag: YPL131W
See related: AllianceGenome:SGD:S000006052; FungiDB:YPL131W; VEuPathDB:YPL131W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPI14; RPL1
Summary: Enables 5S rRNA binding activity. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RPL5 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (303121..304014)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of Cgr1 results in inhibition of 5S ribonucleoprotein(RNP) rotation, but suppressor mutations mapping in factors Rpf2, Rrs1, and Rpl5, stabilizing the pre-rotational stage of the 5S RNP, partly overcome this defect.
Title: Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.
study identifies a transport adaptor, symportin 1 (Syo1)Ydl063c, that facilitates synchronized coimport of the 5S-rRNA binding proteins Rpl5 and Rpl11; symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes
Title: Synchronizing nuclear import of ribosomal proteins with ribosome assembly.
identified a ribonucleoprotein neighborhood in preribosomes that contains two ribosome assembly factors, Rpf2 and Rrs1, two ribosomal proteins, rpL5 and rpL11, and 5S rRNA
Title: Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 5S rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 5S rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables 5S rRNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IC Inferred by Curator more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in ribosomal large subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 60S subunit protein L5

NP_015194.1

Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

303121..304014

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183945.1 → NP_015194.1 TPA: ribosomal 60S subunit protein L5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015194.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3N6, P26321

UniProtKB/TrEMBL

A6ZWC1, B3LKU4, B5VT34, C7GJ84, C8ZIP9, G2WP50, N1P1H9

Conserved Domains (1) summary

PTZ00069
Location:1 → 282

PTZ00069; 60S ribosomal protein L5; Provisional