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KAP120 karyopherin KAP120 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855978, updated on 4-Jan-2025

Summary

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Official Symbol
KAP120
Official Full Name
karyopherin KAP120
Primary source
SGD:S000006046
Locus tag
YPL125W
See related
AllianceGenome:SGD:S000006046; FungiDB:YPL125W; VEuPathDB:YPL125W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPH2
Summary
Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO11 (importin 11). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See KAP120 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (313388..316486)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histone H1 Neighboring gene Nan1p Neighboring gene Spc29p Neighboring gene ribonuclease T2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway. Chattopadhyay S, et al. Nat Commun, 2022 Nov 23. PMID 36418294, Free PMC Article
  2. Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid. Butterfield-Gerson KL, et al. J Virol, 2006 Feb. PMID 16439536, Free PMC Article
  3. Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Kim KY, et al. Mol Biol Cell, 2010 May 1. PMID 20219973, Free PMC Article
  4. Nuclear import of ho endonuclease utilizes two nuclear localization signals and four importins of the ribosomal import system. Bakhrat A, et al. J Biol Chem, 2006 May 5. PMID 16507575
  5. Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus. Süel KE, et al. J Biol Chem, 2009 Jun 5. PMID 19366694, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KAP120 functions as a nuclear import receptor for ribosome assembly factor RPF1.
    Title: Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
karyopherin KAP120
NP_015200.1
  • Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    313388..316486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183939.1 → NP_015200.1  TPA: karyopherin KAP120 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P2, Q02932
    UniProtKB/TrEMBL
    B5VT40, C7GJ79, C8ZIQ4, N1NX29
    Conserved Domains (1) summary
    COG5657
    Location:8 → 1023
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02932.1

Gene LinkOut

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