MSD1 aspartate--tRNA ligase MSD1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MSD1
Official Full Name: aspartate--tRNA ligase MSD1
Primary source: SGD:S000006025
Locus tag: YPL104W
See related: AllianceGenome:SGD:S000006025; FungiDB:YPL104W; VEuPathDB:YPL104W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPG5
Summary: Enables aspartate-tRNA ligase activity. Involved in mitochondrial aspartyl-tRNA aminoacylation. Located in mitochondrion. Used to study leukodystrophy. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MSD1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (355700..357676)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of AspRS is regulated in yeast by a feedback mechanism that necessitates the binding of AspRS to its messenger RNA.
Title: tRNA-balanced expression of a eukaryal aminoacyl-tRNA synthetase by an mRNA-mediated pathway.
N-terminal extension of each aspartyl-tRNA synthetase subunit plays a crucial role in anchoring the tRNA-like motifs of the mRNA on the synthetase
Title: An intricate RNA structure with two tRNA-derived motifs directs complex formation between yeast aspartyl-tRNA synthetase and its mRNA.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables aspartate-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables aspartate-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aspartate-tRNA ligase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aspartyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial aspartyl-tRNA aminoacylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial aspartyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: aspartate--tRNA ligase MSD1

NP_015221.1

EC 6.1.1.12

Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

355700..357676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183918.1 → NP_015221.1 TPA: aspartate--tRNA ligase MSD1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015221.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3R3, P15179

UniProtKB/TrEMBL

A6ZWE7, B3LKW9, N1NVG9

Conserved Domains (1) summary

TIGR00459
Location:35 → 658

aspS_bact; aspartyl-tRNA synthetase, bacterial type