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MSY1 tyrosine--tRNA ligase MSY1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856007, updated on 4-Jan-2025

Summary

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Official Symbol
MSY1
Official Full Name
tyrosine--tRNA ligase MSY1
Primary source
SGD:S000006018
Locus tag
YPL097W
See related
AllianceGenome:SGD:S000006018; FungiDB:YPL097W; VEuPathDB:YPL097W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tyrosine-tRNA ligase activity. Involved in mitochondrial tyrosyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MSY1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (364952..366430)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ina17p Neighboring gene Mgr2p Neighboring gene Eri1p Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo. Edwards H, et al. Cell, 1987 Nov 20. PMID 3315228
  2. The yeast model suggests the use of short peptides derived from mt LeuRS for the therapy of diseases due to mutations in several mt tRNAs. Di Micco P, et al. Biochim Biophys Acta, 2014 Dec. PMID 25261707
  3. RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae. Imamura Y, et al. PLoS One, 2015. PMID 26086550, Free PMC Article
  4. The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Kochan DZ, et al. J Cell Sci, 2021 Aug 1. PMID 34350963, Free PMC Article
  5. A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Wilfling F, et al. Mol Cell, 2020 Dec 3. PMID 33207182, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tyrosine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial tyrosyl-tRNA aminoacylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tyrosine--tRNA ligase MSY1
NP_015228.1
  • Mitochondrial tyrosyl-tRNA synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    364952..366430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183911.1 → NP_015228.1  TPA: tyrosine--tRNA ligase MSY1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015228.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3R9, P48527
    UniProtKB/TrEMBL
    A6ZWF3, B3LKX5, B5VT64, N1NW33
    Conserved Domains (1) summary
    TIGR00234
    Location:54 → 471
    tyrS; tyrosyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48527.1

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