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OAZ1 Oaz1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856055, updated on 9-Dec-2024

Summary

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Official Symbol
OAZ1
Official Full Name
Oaz1p
Primary source
SGD:S000005973
Locus tag
YPL052W
See related
AllianceGenome:SGD:S000005973; FungiDB:YPL052W; VEuPathDB:YPL052W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YPL052W-A
Summary
Enables ornithine decarboxylase inhibitor activity. Involved in negative regulation of translational frameshifting and regulation of proteasomal protein catabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See OAZ1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (458799..459678)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Lee1p Neighboring gene putative mannosyltransferase Neighboring gene Arf family GTPase ARL3 Neighboring gene mannosyltransferase complex subunit MNN9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. Palanimurugan R, et al. EMBO J, 2004 Dec 8. PMID 15538383, Free PMC Article
  2. Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA. Kurian L, et al. Nature, 2011 Sep 7. PMID 21900894
  3. Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae. Halwas K, et al. Int J Mol Sci, 2022 Oct 26. PMID 36361762, Free PMC Article
  4. Epigenetic control of polyamines by the prion [PSI+]. Namy O, et al. Nat Cell Biol, 2008 Sep. PMID 19160487
  5. Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex. Chattopadhyay MK, et al. Biochem Biophys Res Commun, 2011 Mar 11. PMID 21295540, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae.
    Title: Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae.
  2. The molecular weight of the ODC:AZ complex is 90 kDa, which indicates a one to one stoichiometric binding of AZ and ODC in vitro.
    Title: Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex.
  3. Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme
    Title: Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme.
  4. Data suggest that polyamines inhibit their ornithine decarboxylase-mediated biosynthesis by two mechanisms, the control of Oaz1 synthesis and inhibition of its degradation.
    Title: Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of translational frameshifting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Oaz1p
NP_015273.2
  • Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    458799..459678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183866.4 → NP_015273.2  TPA: Oaz1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015273.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3W2, Q02803
    UniProtKB/TrEMBL
    G2WPC6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02803.2

Gene LinkOut

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