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EGD1 Egd1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856070, updated on 9-Dec-2024

Summary

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Official Symbol
EGD1
Official Full Name
Egd1p
Primary source
SGD:S000005958
Locus tag
YPL037C
See related
AllianceGenome:SGD:S000005958; FungiDB:YPL037C; VEuPathDB:YPL037C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in cotranslational protein targeting to membrane and macroautophagy. Acts upstream of or within mitophagy. Part of nascent polypeptide-associated complex. Orthologous to human BTF3 (basic transcription factor 3) and BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EGD1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (481428..481901, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Met31p Neighboring gene H(+)-exporting P2-type ATPase PMA2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The EGD1 product, a yeast homolog of human BTF3, may be involved in GAL4 DNA binding. Parthun MR, et al. Mol Cell Biol, 1992 Dec. PMID 1448098, Free PMC Article
  2. Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo. Hu GZ, et al. Nucleic Acids Res, 1994 Jul 25. PMID 8052529, Free PMC Article
  3. The yeast EGD2 gene encodes a homologue of the alpha NAC subunit of the human nascent-polypeptide-associated complex. Shi X, et al. Gene, 1995 Nov 20. PMID 8522175
  4. Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. Franke J, et al. J Cell Sci, 2001 Jul. PMID 11683391
  5. The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast. Tian Y, et al. Sci Rep, 2024 Jan 4. PMID 38177147, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast.
    Title: The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast.
  2. Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
    Title: Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, no-go-decay and autophagy.
  3. Study reports that EGD1 mRNA is localized in a novel cytoplasmic inclusion, named EGD1 granule, when EGD1 is expressed excessively compared to EGD2 in S. cerevisiae.
    Title: EGD1 (β-NAC) mRNA is localized in a novel cytoplasmic structure in Saccharomyces cerevisiae.
  4. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
    Title: Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cotranslational protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Egd1p
NP_015288.1
  • Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting to mitochondria; peripheral component of cytoplasmic ribosomes; regulates Atg32p phosphorylation to promote respiration-induced mitophagy; enhances DNA binding of the Gal4p; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    481428..481901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183851.1 → NP_015288.1  TPA: Egd1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015288.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZWL1, D6W3X7, Q02107, Q02642
    UniProtKB/TrEMBL
    B3LL28, C7GU17, C8ZIZ2, G2WPE2, N1NXB6
    Conserved Domains (1) summary
    cd22055
    Location:9 → 125
    NAC_BTF3; basal transcription factor BTF3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02642.2

Gene LinkOut

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