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RMI1 Rmi1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856083, updated on 9-Dec-2024

Summary

Official Symbol
RMI1
Official Full Name
Rmi1p
Primary source
SGD:S000005945
Locus tag
YPL024W
See related
AllianceGenome:SGD:S000005945; FungiDB:YPL024W; VEuPathDB:YPL024W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NCE4
Summary
Enables enzyme activator activity; four-way junction DNA binding activity; and single-stranded DNA binding activity. Involved in DNA damage response; DNA topological change; and mitotic sister chromatid cohesion. Located in nuclear replication fork. Part of RecQ family helicase-topoisomerase III complex. Used to study primary ovarian insufficiency. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See RMI1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (503517..504242)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Sma1p Neighboring gene putative serine/threonine protein kinase SKS1 Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET12 Neighboring gene ssDNA endodeoxyribonuclease RAD1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables four-way junction DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Rmi1p
NP_015301.1
  • Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    503517..504242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183838.1NP_015301.1  TPA: Rmi1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015301.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y8, Q02685
    UniProtKB/TrEMBL
    A6ZWM2, B3LL39, B5VTD8, C7GU27, C8ZJ04, G2WPF4, N1NVI5
    Conserved Domains (1) summary
    pfam08585
    Location:49215
    RMI1_N; RecQ mediated genome instability protein