VTC3 vacuolar transporter chaperone [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: VTC3
Official Full Name: vacuolar transporter chaperone
Primary source: SGD:S000005940
Locus tag: YPL019C
See related: AllianceGenome:SGD:S000005940; FungiDB:YPL019C; VEuPathDB:YPL019C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PHM2
Summary: Enables calmodulin binding activity. Involved in several processes, including microautophagy; polyphosphate metabolic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum and fungal-type vacuole membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in microautophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in microautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyphosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polyphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar transporter chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar transporter chaperone complex	IEA Inferred from Electronic Annotation more info
part_of vacuolar transporter chaperone complex	IPI Inferred from Physical Interaction more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_015306.1

Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC3 has a paralog, VTC2, that arose from the whole genome duplication

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