HST2 histone deacetylase HST2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HST2
Official Full Name: histone deacetylase HST2
Primary source: SGD:S000005936
Locus tag: YPL015C
See related: AllianceGenome:SGD:S000005936; FungiDB:YPL015C; VEuPathDB:YPL015C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables histone deacetylase activity, NAD-dependent. Involved in negative regulation of mitotic recombination and rDNA heterochromatin formation. Located in cytoplasm and nucleus. Orthologous to several human genes including SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See HST2 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (525810..526883, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

14-3-3 Protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2.
Title: 14-3-3 Protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2.
Data show that Sir2, and not Hst2, regulates the acetylation state of H3 lysine 79.
Title: Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.
Specific functions were found for HST2.
Title: Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.
results show that HST2 is responsible for Sir2-independent life-span extension by calorie restriction and that it does so by suppressing rDNA recombination, the same mechanism by which SIR2 extends life span
Title: HST2 mediates SIR2-independent life-span extension by calorie restriction.
Here, we show that Hst2 moves between the nucleus and cytoplasm, but is largely cytoplasmic owing to efficient nuclear export.Disruption of Hst2 export shows that nuclear exclusion inhibits the activity of Hst2 as a transcriptional repressor.
Title: Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rDNA heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone deacetylase HST2

NP_015310.1

EC 2.3.1.286

Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

525810..526883 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183829.1 → NP_015310.1 TPA: histone deacetylase HST2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015310.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3Z7, P53686

UniProtKB/TrEMBL

A6ZWN1, B3LL47

Conserved Domains (1) summary

cd01408
Location:26 → 277

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...