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RRP12 mRNA-binding protein RRP12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856095, updated on 9-Dec-2024

Summary

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Official Symbol
RRP12
Official Full Name
mRNA-binding protein RRP12
Primary source
SGD:S000005933
Locus tag
YPL012W
See related
AllianceGenome:SGD:S000005933; FungiDB:YPL012W; VEuPathDB:YPL012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleus. Part of 90S preribosome. Orthologous to human RRP12 (ribosomal RNA processing 12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RRP12 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (529723..533409)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cip1p Neighboring gene mitochondrial 37S ribosomal protein MRPS16 Neighboring gene Taf3p Neighboring gene coatomer subunit zeta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Making ribosomes. Fatica A, et al. Curr Opin Cell Biol, 2002 Jun. PMID 12067653
  2. TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export. Vanrobays E, et al. RNA, 2008 Oct. PMID 18755838, Free PMC Article
  3. SUT1p interaction with Cyc8p(Ssn6p) relieves hypoxic genes from Cyc8p-Tup1p repression in Saccharomyces cerevisiae. Régnacq M, et al. Mol Microbiol, 2001 Jun. PMID 11401714
  4. A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits. Oeffinger M, et al. Genes Dev, 2004 Jan 15. PMID 14729571, Free PMC Article
  5. Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast. Moriggi G, et al. RNA, 2017 Sep. PMID 28588079, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) TAS
Traceable Author Statement
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
mRNA-binding protein RRP12
NP_015313.1
  • Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    529723..533409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183826.1 → NP_015313.1  TPA: mRNA-binding protein RRP12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015313.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W400, Q12754, Q7LH12
    UniProtKB/TrEMBL
    A6ZWN4, B3LL50, N1NW64
    Conserved Domains (1) summary
    pfam08161
    Location:414 → 615
    NUC173; NUC173 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12754.1

Gene LinkOut

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