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LTP1 tyrosine protein phosphatase LTP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856187, updated on 9-Dec-2024

Summary

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Official Symbol
LTP1
Official Full Name
tyrosine protein phosphatase LTP1
Primary source
SGD:S000006277
Locus tag
YPR073C
See related
AllianceGenome:SGD:S000006277; FungiDB:YPR073C; VEuPathDB:YPR073C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein tyrosine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LTP1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (691933..692418, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene CCR4-NOT core subunit NOT5 Neighboring gene transketolase TKL1 Neighboring gene Opy2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase. Ostanin K, et al. J Biol Chem, 1995 Aug 4. PMID 7629177
  2. Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate. Wang S, et al. Biochemistry, 2000 Feb 29. PMID 10684639
  3. Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1. Paoli P, et al. Biochim Biophys Acta, 2007 May. PMID 17296269
  4. The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1. Magherini F, et al. Biochem Biophys Res Commun, 2004 Aug 20. PMID 15358193
  5. Identification of putative negative regulators of yeast signaling through a screening for protein phosphatases acting on cell wall integrity and mating MAPK pathways. Sacristán-Reviriego A, et al. Fungal Genet Biol, 2015 Apr. PMID 25736922

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The site-directed mutagenesis of two aromatic residues lining the active site pocket of LTP1 was studied.
    Title: Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
tyrosine protein phosphatase LTP1
NP_015398.1
  • Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    691933..692418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184170.1 → NP_015398.1  TPA: tyrosine protein phosphatase LTP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015398.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W477, P40347
    UniProtKB/TrEMBL
    A6ZWW0, B3LLC6, C7GXZ9, C8ZJ98, G2WPP5, N1NWD4
    Conserved Domains (1) summary
    cd00115
    Location:9 → 158
    LMWP; Low molecular weight phosphatase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40347.1

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