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ISR1 putative protein kinase ISR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856221, updated on 4-Jan-2025

Summary

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Official Symbol
ISR1
Official Full Name
putative protein kinase ISR1
Primary source
SGD:S000006310
Locus tag
YPR106W
See related
AllianceGenome:SGD:S000006310; FungiDB:YPR106W; VEuPathDB:YPR106W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein kinase activity. Involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process; peptidyl-serine phosphorylation; and peptidyl-threonine phosphorylation. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ISR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (740061..741392)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Fhl1p Neighboring gene Golgi transport complex subunit COG4 Neighboring gene cleavage polyadenylation factor RNA-binding subunit YTH1 Neighboring gene proteasome regulatory particle lid subunit RPN7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Miyahara K, et al. Biosci Biotechnol Biochem, 1998 Jul. PMID 9720220
  2. Redundant targeting of Isr1 by two CDKs in mitotic cells. Alme EB, et al. Curr Genet, 2021 Feb. PMID 33063175, Free PMC Article
  3. Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1. Mehlgarten C, et al. FEMS Yeast Res, 2007 Aug. PMID 17367514
  4. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. Alme EB, et al. PLoS Genet, 2020 Jun. PMID 32579556, Free PMC Article
  5. Combining chemical genetics and proteomics to identify protein kinase substrates. Dephoure N, et al. Proc Natl Acad Sci U S A, 2005 Dec 13. PMID 16330754, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Redundant targeting of Isr1 by two CDKs in mitotic cells.
    Title: Redundant targeting of Isr1 by two CDKs in mitotic cells.
  2. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.
    Title: The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.
  3. In sum, high-copy ISR1 and UGP1 cells affect early steps of the zymocin response and potentially prevent the lethal K. lactis killer complex from establishing cell surface recognition and/or contact.
    Title: Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative protein kinase ISR1
NP_015431.1
  • Predicted protein kinase; negatively regulates the hexosamine biosynthetic pathway (HBP), which converts fructose-6-phosphate into UDP-N-acetylglucosamine, a precursor of chitin biosynthesis, GPI-anchor formation and glycosylation; interacts genetically with GFA1, encoding the first enzyme in the HBP; involved in Gfa1p phosphorylation (S332, T334); contains a Pho85p-regulated SCF-CDC4 phosphodegron; unstable, cell cycle regulated protein, peaking at G1/S

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    740061..741392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184203.1 → NP_015431.1  TPA: putative protein kinase ISR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015431.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4A4, Q06098
    UniProtKB/TrEMBL
    A6ZWY6, B5VTP6, C7GXR7, N1NWF6
    Conserved Domains (1) summary
    cl21453
    Location:142 → 372
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06098.1

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