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DBF20 serine/threonine-protein kinase DBF20 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856227, updated on 9-Dec-2024

Summary

Official Symbol
DBF20
Official Full Name
serine/threonine-protein kinase DBF20
Primary source
SGD:S000006315
Locus tag
YPR111W
See related
AllianceGenome:SGD:S000006315; FungiDB:YPR111W; VEuPathDB:YPR111W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including division septum assembly; exit from mitosis; and regulation of mRNA catabolic process. Located in cellular bud neck and spindle pole body. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See DBF20 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (747306..749000)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Gld1p Neighboring gene DNA-directed RNA polymerase core subunit RPC40 Neighboring gene RNA-binding ribosome biosynthesis protein MRD1 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in division septum assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exit from mitosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm HDA PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase DBF20
NP_015436.1
  • Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    747306..749000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184208.1NP_015436.1  TPA: serine/threonine-protein kinase DBF20 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015436.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4B0, E9P8X8, P32328, Q06105
    UniProtKB/TrEMBL
    B3LK75, B5VTQ1, N1NXQ2
    Conserved Domains (1) summary
    cd05600
    Location:157539
    STKc_Sid2p_like; Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases