pyridoxine 4-dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Full Name: pyridoxine 4-dehydrogenase
Primary source: SGD:S000006331
Locus tag: YPR127W
See related: AllianceGenome:SGD:S000006331; FungiDB:YPR127W; VEuPathDB:YPR127W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable aldo-keto reductase (NADPH) activity. Predicted to be involved in vitamin B6 catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (790083..791120)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxine:NADP 4-dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in vitamin B6 catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyridoxine 4-dehydrogenase

NP_015452.1

EC 1.1.1.65

Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

790083..791120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184224.1 → NP_015452.1 TPA: pyridoxine 4-dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015452.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4C4, Q06494

UniProtKB/TrEMBL

A6ZX06, C8ZJE9, N1NXS1

Conserved Domains (1) summary

cd19077
Location:8 → 329

AKR_AKR8A1-2; AKR8A family of aldo-keto reductase (AKR)