NAT3 peptide alpha-N-acetyltransferase complex B subunit NAT3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NAT3
Official Full Name: peptide alpha-N-acetyltransferase complex B subunit NAT3
Primary source: SGD:S000006335
Locus tag: YPR131C
See related: AllianceGenome:SGD:S000006335; FungiDB:YPR131C; VEuPathDB:YPR131C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NAA20; RAD56
Summary: Enables peptide alpha-N-acetyltransferase activity. Involved in several processes, including ERAD pathway; N-terminal peptidyl-methionine acetylation; and mitochondrion inheritance. Located in cytoplasm. Part of NatB complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NAT3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (793911..794498, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Function and molecular mechanism of N-terminal acetylation in autophagy.
Title: Function and molecular mechanism of N-terminal acetylation in autophagy.
Data indicate that in preventing Der1 acetylation stimulates its proteolysis via the Hrd1 pathway, at least partially accounting for the endoplasmic reticulum-associated protein degradation (ERAD) defect observed in the absence of NatB.
Title: N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide alpha-N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in N-terminal peptidyl-methionine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NatB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatB complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptide alpha-N-acetyltransferase complex B subunit NAT3

NP_015456.2

EC 2.3.1.254

Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

793911..794498 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184228.1 → NP_015456.2 TPA: peptide alpha-N-acetyltransferase complex B subunit NAT3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015456.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4C7, Q06504

UniProtKB/TrEMBL

A6ZX09, B3LK92, C7GLJ1, C8ZJF3, G2WPU5, N1NWI2

Conserved Domains (1) summary

COG0456
Location:1 → 160

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]