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TOM5 Tom5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856252, updated on 9-Dec-2024

Summary

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Official Symbol
TOM5
Official Full Name
Tom5p
Primary source
SGD:S000006433
Locus tag
YPR133W-A
See related
AllianceGenome:SGD:S000006433; FungiDB:YPR133W-A; VEuPathDB:YPR133W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MOM8A
Summary
Contributes to protein transmembrane transporter activity. Involved in mitochondrial outer membrane translocase complex assembly and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TOM5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (797557..797709)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S23B Neighboring gene Spn1p Neighboring gene Mss18p Neighboring gene chromatin-binding protein CTF4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the cytosolic domain of TOM5, a mitochondrial import protein. Hammen PK, et al. FEBS Lett, 2000 Feb 18. PMID 10683449
  2. Targeting and assembly of mitochondrial tail-anchored protein Tom5 to the TOM complex depend on a signal distinct from that of tail-anchored proteins dispersed in the membrane. Horie C, et al. J Biol Chem, 2003 Oct 17. PMID 12896971
  3. Just follow the acid chain. Schatz G. Nature, 1997 Jul 10. PMID 9217147
  4. Nucleo-mitochondrial interaction of yeast in response to cadmium sulfide quantum dot exposure. Pasquali F, et al. J Hazard Mater, 2017 Feb 15. PMID 27890358
  5. Role of Tom5 in maintaining the structural stability of the TOM complex of mitochondria. Schmitt S, et al. J Biol Chem, 2005 Apr 15. PMID 15701639

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Daya suggest that the assembly of newly imported Tom40 is directly initiated at the SAM complex (SAM37) by its association with Tom5.
    Title: Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial outer membrane translocase complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial outer membrane translocase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tom5p
NP_015459.1
  • Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    797557..797709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184307.1 → NP_015459.1  TPA: Tom5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4D0, P80967
    UniProtKB/TrEMBL
    A6ZX11, B3LK95, B5VTR9, C7GLJ4, C8ZJF6, G2WPU8, N1NVL5
    Conserved Domains (1) summary
    pfam10642
    Location:1 → 47
    Tom5; Mitochondrial import receptor subunit or translocase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80967.1

Gene LinkOut

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