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LOA1 lysophosphatidic acid acyltransferase LOA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856261, updated on 9-Dec-2024

Summary

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Official Symbol
LOA1
Official Full Name
lysophosphatidic acid acyltransferase LOA1
Primary source
SGD:S000006343
Locus tag
YPR139C
See related
AllianceGenome:SGD:S000006343; FungiDB:YPR139C; VEuPathDB:YPR139C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VPS66
Summary
Enables lysophosphatidic acid acyltransferase activity. Involved in intracellular triglyceride homeostasis and lipid droplet organization. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LOA1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (813156..814058, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene ammonium permease MEP3 Neighboring gene lysophosphatidylcholine acyltransferase Neighboring gene Kar3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipids containing medium-chain fatty acids are specific to post-whole genome duplication Saccharomycotina yeasts. Froissard M, et al. BMC Evol Biol, 2015 May 28. PMID 26018144, Free PMC Article
  2. YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis. Ayciriex S, et al. Mol Biol Cell, 2012 Jan. PMID 22090344, Free PMC Article
  3. Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome. Grillitsch K, et al. Biochim Biophys Acta, 2011 Dec. PMID 21820081, Free PMC Article
  4. Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p. Han S, et al. BMC Cell Biol, 2015 Dec 4. PMID 26637296, Free PMC Article
  5. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loa1p is therefore a novel lysophosphatidic acid acyltransferase and plays a role in lipid droplets formation.
    Title: YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole HMP PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysophosphatidic acid acyltransferase LOA1
NP_015465.1
  • Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    813156..814058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184236.1 → NP_015465.1  TPA: lysophosphatidic acid acyltransferase LOA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4D7, Q06508
    UniProtKB/TrEMBL
    A6ZX16, B3LKA0, B5VTS6, C7GLJ9, C8ZJG2, G2WPV3, N1NVL6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06508.1

Gene LinkOut

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