RPC82 DNA-directed RNA polymerase III subunit C82 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPC82
Official Full Name: DNA-directed RNA polymerase III subunit C82
Primary source: SGD:S000006394
Locus tag: YPR190C
See related: AllianceGenome:SGD:S000006394; FungiDB:YPR190C; VEuPathDB:YPR190C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPC3; RPC80
Summary: Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RPC82 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (917077..919041, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TFIIE-related Rpc82 subunit of RNA polymerase III interacts with the TFIIB-related transcription factor Brf1 and the polymerase cleft for transcription initiation.
Title: The TFIIE-related Rpc82 subunit of RNA polymerase III interacts with the TFIIB-related transcription factor Brf1 and the polymerase cleft for transcription initiation.
TORC1-dependent sumoylation of Rpc82 in particular is required for robust tRNA transcription. Mechanistically, sumoylation of Rpc82 is important for assembly of the RNAPIII holoenzyme and recruitment of Rpc82 to tRNA genes.
Title: TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA polymerase III activity	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit C82

NP_015516.1

RNA polymerase III subunit C82

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

917077..919041 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184287.1 → NP_015516.1 TPA: DNA-directed RNA polymerase III subunit C82 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015516.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZX64, D6W4J0, P32349, Q06591

UniProtKB/TrEMBL

B3LKE9, B5VTW9, C7GP71, C8ZJL9, N1NWL2

Conserved Domains (2) summary

pfam05645
Location:189 → 487

RNA_pol_Rpc82; RNA polymerase III subunit RPC82

pfam08221
Location:47 → 109

HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain