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GUT1 glycerol kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856353, updated on 9-Dec-2024

Summary

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Official Symbol
GUT1
Official Full Name
glycerol kinase
Primary source
SGD:S000001024
Locus tag
YHL032C
See related
AllianceGenome:SGD:S000001024; FungiDB:YHL032C; VEuPathDB:YHL032C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glycerol kinase activity. Involved in glycerol metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase); GK2 (glycerol kinase 2); and GK3 (glycerol kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GUT1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (36379..38508, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Sbp1p Neighboring gene ribosomal 60S subunit protein L8A Neighboring gene Gos1p Neighboring gene Ecm29p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism. Sprague GF, et al. J Bacteriol, 1977 Mar. PMID 191434, Free PMC Article
  2. Carbon source-dependent transcriptional regulation of the mitochondrial glycerol-3-phosphate dehydrogenase gene, GUT2, from Saccharomyces cerevisiae. Grauslund M, et al. Can J Microbiol, 2000 Dec. PMID 11142398
  3. Saccharomyces cerevisiae exhibiting a modified route for uptake and catabolism of glycerol forms significant amounts of ethanol from this carbon source considered as 'non-fermentable'. Aßkamp MR, et al. Biotechnol Biofuels, 2019. PMID 31695748, Free PMC Article
  4. The sole introduction of two single-point mutations establishes glycerol utilization in Saccharomyces cerevisiae CEN.PK derivatives. Ho PW, et al. Biotechnol Biofuels, 2017. PMID 28053667, Free PMC Article
  5. Sir2 and Glycerol Underlie the Pro-Longevity Effect of Quercetin during Yeast Chronological Aging. Abbiati F, et al. Int J Mol Sci, 2023 Jul 31. PMID 37569599, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycerol kinase
NP_011831.1
  • Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    36379..38508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179112.1 → NP_011831.1  TPA: glycerol kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011831.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKT6, P32190
    UniProtKB/TrEMBL
    A6ZSL8, B3LS87, C7GIQ4
    Conserved Domains (1) summary
    cl17037
    Location:46 → 685
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32190.1

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