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NMD2 Nmd2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856476, updated on 9-Dec-2024

Summary

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Official Symbol
NMD2
Official Full Name
Nmd2p
Primary source
SGD:S000001119
Locus tag
YHR077C
See related
AllianceGenome:SGD:S000001119; FungiDB:YHR077C; VEuPathDB:YHR077C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
IFS1; SUA1; SUP111; UPF2
Summary
Predicted to enable RNA binding activity. Involved in DNA recombination and nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Located in cytoplasm. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NMD2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (252374..255756, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase methylesterase 1 Neighboring gene type 2C protein phosphatase PTC7 Neighboring gene uncharacterized protein Neighboring gene bifunctional endoribonuclease/protein kinase IRE1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiae. Culbertson MR, et al. RNA, 2005 Sep. PMID 16043493, Free PMC Article
  2. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Cui Y, et al. Genes Dev, 1995 Feb 15. PMID 7883167
  3. Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast. He F, et al. RNA, 1996 Feb. PMID 8601282, Free PMC Article
  4. Nonsense-mediated decay mutants do not affect programmed -1 frameshifting. Bidou L, et al. RNA, 2000 Jul. PMID 10917592, Free PMC Article
  5. Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance. Muhlrad D, et al. RNA, 1999 Oct. PMID 10573121, Free PMC Article

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upf2p phosphorylation is crucial for nonsense-mediated mRNA decay (NMD) pathway.
    Title: Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Nmd2p
NP_011944.2
  • Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; acts as a scaffold protein bridging Nam7p and Upf3p; involved in telomere maintenance; contains an acidic domain and three middle domains of eukaryotic initiation factor 4G (mIF4G) with aspartic 59 of mIF4G-1 important for NMD activity and translation termination accuracy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    252374..255756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179207.1 → NP_011944.2  TPA: Nmd2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011944.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL27, P38798
    UniProtKB/TrEMBL
    B3LSJ5
    Conserved Domains (3) summary
    smart00543
    Location:374 → 561
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02854
    Location:34 → 241
    MIF4G; MIF4G domain
    pfam04050
    Location:976 → 1084
    Upf2; Up-frameshift suppressor 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38798.2

Gene LinkOut

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