U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UBA4 Uba4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856511, updated on 9-Dec-2024

Summary

Official Symbol
UBA4
Official Full Name
Uba4p
Primary source
SGD:S000001153
Locus tag
YHR111W
See related
AllianceGenome:SGD:S000001153; FungiDB:YHR111W; VEuPathDB:YHR111W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YHR1
Summary
Enables AMPylase activity; URM1 activating enzyme activity; and thiosulfate sulfurtransferase activity. Involved in several processes, including invasive growth in response to glucose limitation; protein urmylation; and tRNA wobble position uridine thiolation. Located in cytoplasm. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UBA4 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (333072..334394)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene cytochrome c lysine N-methyltransferase Neighboring gene Erp5p Neighboring gene putative cystathionine beta-lyase Neighboring gene aspartyl aminopeptidase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables AMPylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables URM1 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables URM1 activating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfurtransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thiosulfate sulfurtransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in cell budding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in invasive growth in response to glucose limitation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein urmylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein urmylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein urmylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein urmylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA wobble position uridine thiolation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble position uridine thiolation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Uba4p
NP_011979.1
  • E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    333072..334394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179241.1NP_011979.1  TPA: Uba4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZT19, B3LSM6, B5VK45, D3DL61, P38820
    UniProtKB/TrEMBL
    C7GLZ7, C8Z9Q4, G2WFI5, N1P4N4
    Conserved Domains (2) summary
    cd00757
    Location:46279
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    cd01526
    Location:316440
    RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...